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General Information
- General Information
  - General Information Data Description
    - AJCSD_ID C004-716-18A CAS RN 75-86-5
      
      Chemical Substance Name 2-Hydroxy-2-methylpropanenitrile
      
      Molecular Formula C4H7NO
      
      Molecular Weight 85
      
      SMILES N#CC(C)(O)C
      
      Structure
- Synonym
  - Synonym Data Description
    - Synonym 2-Cyanopropan-2-ol
      
      2-Hydroxy-2-methyl propionitrile
      
      2-hydroxy-2-methylpropionitrile
      
      2-Methyl-lactonitrile
      
      Acetone cyanhydrin
      
      Acetone cyanohydrin
      
      p-Hydroxyisobutyronitrile

Laws and Regulations

Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	2-1539	Category	Section 2
Chemical Substance Name	Acetone cyanohydrin
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Act on Confirmation, etc. of Release Amounts of Specific Chemical Substances in the Environment and Promotion of Improvements to the Management Thereof(PRTR-SDS Law)
- Japan: PRTR-SDS Law (until March 2023) Data Description Outline PRTR Law (METI site) Analysis of PRTR data
  - Classification I Cabinet Order Number
    1-14
    
    Cabinet Order Name Acetone cyanohydrin
    
    Remarks -
    
    Basis of selection Hazard Data (in Japanese)
- Japan: PRTR-SDS Law (from April 2023) Data Description Outline PRTR Law (METI site)
  - JPSN(Japan PRTR-SDS Number)
    14
    Classification I Cabinet Order Number 1-018
    
    Cabinet Order Name Acetone cyanohydrin
    
    Remarks -
    
    Basis of selection Hazard Data (in Japanese)

Industrial Safety and Health Act (ISHA)

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese) Target substances list (MHLW site: in Japanese) Responsibilities of Business Operators (JNIOSH site: in Japanese)

Cabinet Order Number	Attached table 2-59 of Ordinance	Implementation	Effective April 1, 2025
Cabinet Order Name	Acetone cyanohydrin
Range of Application for Label (weight%)	>=1
Range of Application for SDS (weight%)	>=1

Japan ISHA: Concentration standards for the prevention of health problems caused by chemical substances (Concentration standard value setting substance) Data Description Target substances list(MHLW site: in japanese) Responsibilities of Business Operators (JNIOSH site: in Japanese)

Kinds of substances(Substance name)	Acetone cyanohydrin
Short-time concentration standard value	5ppm
Sampling Method	Solid adsorption method
Analytical Method	Gaschromatography
Implementation	2024/04/01

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list, etc.(MHLW site: in japanese) Responsibilities of Business Operators (JNIOSH site: in Japanese)

Substance Name	2-Hydroxy-2-methylpropanenitrile (synonym: Acetone cyanohydrin)
Classification of Target Substances	Skin Absorbing Hazardous Substances	Cutoff value(weight %)	1
Implementation	2024/04/01
Details	to the GHS Classification

Poisonous and Deleterious Substances Control Act

Japan Poisonous and Deleterious Substances Control Act Data Description Link to the Act (MOJ site)

Classification	Deleterious Substances(Cabinet order)	Law or Cabinet Order Number	Article 2-1-32 of Cabinet order
Law or Cabinet Order Name	Organic cyanide compounds and preparations containing it. (except for the items listed as "excluded" in Article 2-1-32 of Cabinet order)

Water Pollution Prevention Act
- Japan Water Pollution Control Law Data Description Water / Soil / Ground Environment (MOE site)
  - Classification Harmful Substances Cabinet Order Number
    Article 2-2 of Cabinet order
    
    Cabinet Order Name Cyanide compounds
    
    Effluent Standards 1mg/L(CN)
    
    Purification Standards N.D.

Soil Contamination Countermeasures Act
- Japan Soil Contamination Countermeasures Act Data Description Water / Soil / Ground Environment (MOE site)
  - Classification Class 2 Cabinet Order Number
    Article 1-5 of Cabinet order
    
    Cabinet Order Name Cyanide compounds
    
    Soil Leachate Standard N.D.(CN)
    
    Soil Concentration Standard 50mg/kg(CN-)

Fire Service Act

Fire Service Act : Hazardous Materials Data Description

Number of cabinet order etc.	Article 2, Paragraph 7 of the Act, Appended Table 1, Category IV (5)
Category; Property	Category IV; Inflammable Liquids
Item	Class III petroleums
Property	Water soluble liquid
Designated quantity	4,000L
Sources	Hazardous Materials Disaster Information Support System, Hazardous Materials Data Book 2nd edition, MHLW Website; Sample SDS

Malaysia
- Use and Standards of Exposure of Chemicals Hazardous to Health (USECHH) Regulation 2000
  - Malaysia: Use and Standards of Exposure of Chemicals Hazardous to Health (USECHH) Regulation 2000 Data Description
    - Category Schedule I
      
      Substance name in English Acetone Cyanohydrin
      
      Substance name in local language -

Philippines
- Toxic Substances and Hazardous and Nuclear Wastes Control Act
  - the Philippines: Toxic Substances and Hazardous and Nuclear Wastes Control Act (RA6969) Data Description
    - Category PICCS
      
      Substance name in English ACETONE CYANOHYDRIN
      
      Substance name in local language -
      
      Related Decree -
      
      Category PICCS
      
      Substance name in English Propanenitrile, 2-hydroxy-2-methyl-
      
      Substance name in local language -
      
      Related Decree -

Vietnam
- Law on Chemical / Luật hóa chất số 06/2007/QH12 ngày 21 tháng 11 năm 2007
  - Viet Nam:Law on Chemical:Decree 113/2017/ND-CP:List of chemicals subject to be restricted in industrial production and trading Data Description Law on Chemical Decree 113/2017/ND-CP Circular 32/2017/TT-BCT National Chemical Database System
    - Substance name in English 2-cyanopropan-2-ol (acetone cyanohydrin)
      
      Substance name in local language -
  - Viet Nam:Law on Chemical:Decree 113/2017/ND-CP:List of chemicals which require developing plan to respond and prevent chemical incident Data Description Law on Chemical Decree 113/2017/ND-CP Circular 32/2017/TT-BCT National Chemical Database System
    - Substance name in English 2-cyanopropan-2-ol (acetone cyanohydrin)
      
      Substance name in local language -
  - Viet Nam:Law on Chemical:Decree 113/2017/ND-CP:List of chemicals subject to compulsory declaration Data Description Law on Chemical Decree 113/2017/ND-CP Circular 32/2017/TT-BCT National Chemical Database System
    - Substance name in English 2-cyanopropan-2-ol (acetone cyanohydrin)
      
      Substance name in local language -
      
      Substance name in English 2-Cyanopropan-2-ol
      
      Substance name in local language -

Chemical Hazard and Risk Information

Japan

GHS Classification Results by the Japanese Government

NITE Japan-GHS Data Description GHS information
- Edition version_2
  
  Chemical Substance Name 2-Hydroxy-2-methylpropanenitrile; Acetone cyanohydrin
  
  Classification Result To the result webpage To the Excel flie

GHS Classification Results by the Japanese Government Data Description GHS Information

Year of implementation /renewal	2006	ID	563_H18_new
Chemical Substance Name	Propanenitrile, 2-hydroxy-2-methyl-
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2009	ID	21B3002
Chemical Substance Name	Acetone cyanohydrin
Classification Result	To the resut webpage To the Excel flie

Year of implementation /renewal	2023	ID	R05-B-012-JNIOSH, MOE
Chemical Substance Name	2-Hydroxy-2-methylpropanenitrile; Acetone cyanohydrin
Classification Result	To the resut webpage To the Excel flie

AJCSD_ID	C004-716-18A	CAS RN	75-86-5
Chemical Substance Name	2-Hydroxy-2-methylpropanenitrile
Molecular Formula	C4H7NO
Molecular Weight	85
SMILES	N#CC(C)(O)C
Structure

Synonym	2-Cyanopropan-2-ol
	2-Hydroxy-2-methyl propionitrile
	2-hydroxy-2-methylpropionitrile
	2-Methyl-lactonitrile
	Acetone cyanhydrin
	Acetone cyanohydrin
	p-Hydroxyisobutyronitrile

Classification	I	Cabinet Order Number	1-14
Cabinet Order Name	Acetone cyanohydrin
Remarks	-
Basis of selection	Hazard Data (in Japanese)

JPSN(Japan PRTR-SDS Number)	14	Classification	I	Cabinet Order Number	1-018
Cabinet Order Name	Acetone cyanohydrin
Remarks	-
Basis of selection	Hazard Data (in Japanese)

Classification	Harmful Substances	Cabinet Order Number	Article 2-2 of Cabinet order
Cabinet Order Name	Cyanide compounds
Effluent Standards	1mg/L(CN)
Purification Standards	N.D.

Classification	Class 2	Cabinet Order Number	Article 1-5 of Cabinet order
Cabinet Order Name	Cyanide compounds
Soil Leachate Standard	N.D.(CN)
Soil Concentration Standard	50mg/kg(CN-)

Category	Schedule I
Substance name in English	Acetone Cyanohydrin
Substance name in local language	-

Category	PICCS
Substance name in English	ACETONE CYANOHYDRIN
Substance name in local language	-
Related Decree	-

Substance name in English	2-cyanopropan-2-ol (acetone cyanohydrin)
Substance name in local language	-

Edition	version_2
Chemical Substance Name	2-Hydroxy-2-methylpropanenitrile; Acetone cyanohydrin
Classification Result	To the result webpage To the Excel flie