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General Information

General Information
- General Information Data Description
  - AJCSD_ID C004-735-23A CAS RN 81-81-2
    
    Chemical Substance Name Warfarin
    
    Molecular Formula C19H16O4
    
    Molecular Weight 308
    
    SMILES OC(C1=C(O2)C=CC=C1)=C(C(CC(C)=O)C3=CC=CC=C3)C2=O
    
    Structure

Synonym

Synonym Data Description

Synonym	2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-
	3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
	3-(alpha-Acetylbenzyl)-4-hydroxycoumarin
	4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one

Laws and Regulations

Japan

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Chemical Substances Control Law ; CSCL)

Japan CSCL: Existing Chemical Substances Data Description Definition of the terms of Section 6 [PDF] Definition of the terms of Section 7 [PDF] Import Clearance Procedures[PDF] Notification of the Manufacturing Amount, etc[PDF]

MITI Number	5-3652	Category	Section 5
Chemical Substance Name	3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
Remarks	-
Details	to J-CHECK
Remarks to Existing Chemical Substances of Industrial Safety and Health Act	Chemicals have been notified in accordance with the provisions of Chemical Substances Control Law by June 29, 1979
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)

Industrial Safety and Health Act (ISHA)

Japan ISHA: Existing Chemical Substances Data Description Existing Chemical Substances (MHLW site : in Japanese) Notification of New Chemical Substances, etc. (MHLW site : in Japanese)

Registration Number	12947
ISHA Number	8-(4)-118
Date of Notification in the Official Gazette	19790630
Chemical Substance Name	3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
Details to Existing Chemical Substances of Industrial Safety and Health Act	to MHLW site (in Japanese)
Note	-

The Registration Number., ISHA Number and Date of Notification in the Official Gazette have been provided by the Ministry of Health, Labour and Welfare.

Japan ISHA: Chemical Substances Requiring Labeling and Delivery of Documents, etc. Data Description GHS compatible model label creation method (MH LW site : in Japanese) Risk assessment implementation support tool (MHLW site : in Japanese) Target substances list (MHLW site: in Japanese) Responsibilities of Business Operators (JNIOSH site: in Japanese)

Cabinet Order Number	Attached table 2-132 of Ordinance	Implementation	Effective April 1, 2025
Cabinet Order Name	3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin (synonym: Warfarin)
Range of Application for Label (weight%)	>=0.3
Range of Application for SDS (weight%)	>=0.1

Japan ISHA: Concentration standards for the prevention of health problems caused by chemical substances (Concentration standard value setting substance) Data Description Target substances list(MHLW site: in japanese) Responsibilities of Business Operators (JNIOSH site: in Japanese)

Kinds of substances(Substance name)	3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin (synonym: Warfarin)
Eight-hour concentration standard value	0.01mg/m3
Sampling Method	Filtration Sampling method
Analytical Method	High performance liquid chromatography
Implementation	2025/10/01

Japan ISHA: Chemical substances that cause skin disorders, etc. and other chemical substances that must be handled with impermeable protective equipment etc. based on special chemical regulations. Data Description Target substances list, etc.(MHLW site: in japanese) Responsibilities of Business Operators (JNIOSH site: in Japanese)

Substance Name	3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin (synonym: Warfarin)
Classification of Target Substances	Skin Absorbing Hazardous Substances	Cutoff value(weight %)	0.3
Implementation	2024/04/01
Details	to the GHS Classification

Malaysia
- Use and Standards of Exposure of Chemicals Hazardous to Health (USECHH) Regulation 2000
  - Malaysia: Use and Standards of Exposure of Chemicals Hazardous to Health (USECHH) Regulation 2000 Data Description
    - Category Schedule I
      
      Substance name in English Warfarin
      
      Substance name in local language -

Philippines
- Toxic Substances and Hazardous and Nuclear Wastes Control Act
  - the Philippines: Toxic Substances and Hazardous and Nuclear Wastes Control Act (RA6969) Data Description
    - Category PICCS
      
      Substance name in English 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-
      
      Substance name in local language -
      
      Related Decree -
      
      Category PICCS
      
      Substance name in English BENZOPYRAN(2H-1)-2-ONE, 4-HYDROXY-3-(3-OXO-1- PHENYLBUTYL)-
      
      Substance name in local language -
      
      Related Decree -

Vietnam
- Law on Chemical / Luật hóa chất số 06/2007/QH12 ngày 21 tháng 11 năm 2007
  - Viet Nam:Law on Chemical:Decree 113/2017/ND-CP:List of chemicals which require developing plan to respond and prevent chemical incident Data Description Law on Chemical Decree 113/2017/ND-CP Circular 32/2017/TT-BCT National Chemical Database System
    - Substance name in English Warfarin ((RS)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one)
      
      Substance name in local language -
  - Viet Nam:Law on Chemical:Decree 113/2017/ND-CP:List of chemicals subject to compulsory declaration Data Description Law on Chemical Decree 113/2017/ND-CP Circular 32/2017/TT-BCT National Chemical Database System
    - Substance name in English Warfarin ((RS)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one)
      
      Substance name in local language -

Chemical Hazard and Risk Information
- Japan
  - GHS Classification Results by the Japanese Government
    - NITE Japan-GHS Data Description GHS information
      - Edition version_1
        
        Chemical Substance Name Warfarin
        
        Classification Result To the result webpage To the Excel flie
    - GHS Classification Results by the Japanese Government Data Description GHS Information
      - Year of implementation /renewal 2006 ID 643_H18_new
        
        Chemical Substance Name Warfarin
        
        Classification Result To the resut webpage To the Excel flie

AJCSD_ID	C004-735-23A	CAS RN	81-81-2
Chemical Substance Name	Warfarin
Molecular Formula	C19H16O4
Molecular Weight	308
SMILES	OC(C1=C(O2)C=CC=C1)=C(C(CC(C)=O)C3=CC=CC=C3)C2=O
Structure

Category	Schedule I
Substance name in English	Warfarin
Substance name in local language	-

Category	PICCS
Substance name in English	2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-
Substance name in local language	-
Related Decree	-

Substance name in English	Warfarin ((RS)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one)
Substance name in local language	-

Edition	version_1
Chemical Substance Name	Warfarin
Classification Result	To the result webpage To the Excel flie

Year of implementation /renewal	2006	ID	643_H18_new
Chemical Substance Name	Warfarin
Classification Result	To the resut webpage To the Excel flie